Neurodevelopment and degeneration

Investigation of neurodevelopment, degeneration and polyphenol induced neuroprotection in Nothobranchius furzeri

The fish, Nothobranchius furzeri, is a short-lived vertebrate of 9 weeks mean longevity. It has been shown that its short life can be modulated using treatment with resveratrol (≈ 30% increase in mean longevity). N. furzeri display a decrease in spontaneous locomotor activity and cognitive ability with advancing age that is tied to the development of neurofibrillary tangles. Resveratrol demonst...

Neurodevelopment and Endocrine Disruption

In this article I explore the possibility that contaminants contribute to the increasing prevalence of attention deficit hyperactivity disorder, autism, and associated neurodevelopmental and behavioral problems in developed countries. I discuss the exquisite sensitivity of the embryo and fetus to thyroid disturbance and provide evidence of human in utero exposure to contaminants that can interf...

Nutrients and neurodevelopment: lipids.

Nutrients, lipids in particular, make up the central nervous system structure and play major functional roles: they stimulate development, migration, and nerve cell differentiation. They are part of gray matter, white matter, nerve nuclei, and synaptogenesis. Breast milk contains lipids which are crucial for infant brain development. The lipid profile of breast milk was used as a guideline for ...

Focus on astroglia and neurodevelopment

Radomska, K. 2014. Functional studies of the Quaking gene. Focus on astroglia and neurodevelopment. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1152. 59 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-8960-1. The RNA-binding protein Quaking (QKI) plays a fundamental role in post-transcriptional gene regulation during mammalian...

Neurotoxic Metal Coexposures and Neurodevelopment